Role of 8-isoprostane, Matrix Gla Protein (MGP) and Bone Morphogenetic Protein-2 (BMP-2) in Vascular Calcification in Chronic Kidney Disease
نویسندگان
چکیده
منابع مشابه
Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
RATIONALE Vascular calcification is a significant contributor to cardiovascular morbidity and mortality. We recently reported that cartilage oligomeric matrix protein (COMP) is pivotal for maintaining the homeostasis of vascular smooth muscle cells (VSMCs). Whether COMP affects the process of vascular calcification is unknown. OBJECTIVE We aimed to test whether COMP modulates vascular calcifi...
متن کاملPolymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction.
The matrix Gla protein (MGP) is an important inhibitor of vessel and cartilage calcification that is strongly expressed in human calcified, atherosclerotic plaques and could modulate plaque calcification and coronary heart disease risk. Using a genetic approach, we explored this possibility by identifying polymorphisms of the MGP gene and testing their possible association with myocardial infar...
متن کاملInhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency
OBJECTIVE Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and mesenchymal transition of endothelial cells (EndMT). In this study, we investigated the contribution...
متن کاملHeat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
RATIONALE Matrix Gla protein (MGP) is a calcification inhibitor, which binds and inhibits bone morphogenetic protein (BMP)-2 and -4. OBJECTIVE The objective was to determine whether MGP also binds other proteins, which could interfere with its function. METHODS AND RESULTS We transfected bovine aortic endothelial cells with N-terminally FLAG-tagged MGP and used immunoprecipitation and liqui...
متن کاملmolecular cloning of bone morphogenetic protein-2 (bmp- 2) in pgem-b1 vector and transformation into e.coli rosetta strain
background: bone morphogenetic protein 2 (bmp- 2) belongs to the tgf-β superfamily of proteins and plays an important role in the development of bone and cartilage. bmp- 2 is also associated with maintenance and repair of damaged bone. recombinant human bone morphogenetic protein 2 (rhbmp- 2) is now produced by genetic engineering techniques and used in treatment of thin bone fractures in the j...
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ژورنال
عنوان ژورنال: The Indonesian Biomedical Journal
سال: 2013
ISSN: 2355-9179,2085-3297
DOI: 10.18585/inabj.v5i2.71